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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARHGEF16
All Species:
16.06
Human Site:
S452
Identified Species:
44.17
UniProt:
Q5VV41
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5VV41
NP_055263.2
709
80105
S452
S
E
R
Y
K
A
A
S
R
A
L
K
A
I
S
Chimpanzee
Pan troglodytes
XP_001159969
661
74693
K408
K
A
A
S
R
A
L
K
A
I
S
K
L
V
R
Rhesus Macaque
Macaca mulatta
XP_001082733
709
80324
S452
S
E
R
Y
K
A
A
S
R
A
L
K
A
I
S
Dog
Lupus familis
XP_849557
1064
116130
S807
P
E
R
Y
K
A
A
S
R
A
L
K
A
I
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3U5C8
713
80377
S456
P
E
R
Y
K
A
A
S
Q
A
L
K
A
I
S
Rat
Rattus norvegicus
Q5BKC9
701
80989
L432
S
E
R
E
G
T
A
L
D
A
H
K
E
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511351
1102
121173
K840
S
P
Q
Y
E
V
C
K
R
A
L
K
E
V
S
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001116755
606
69197
G361
I
E
T
S
E
D
C
G
G
L
P
M
L
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_494706
1136
128641
T832
D
D
R
Y
K
T
A
T
D
A
L
T
S
S
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.8
95.9
54.8
N.A.
81
30.4
N.A.
28.5
N.A.
N.A.
46.2
N.A.
N.A.
N.A.
25.9
N.A.
Protein Similarity:
100
91.4
97.8
59.7
N.A.
89.9
51
N.A.
41.4
N.A.
N.A.
60.3
N.A.
N.A.
N.A.
39.8
N.A.
P-Site Identity:
100
13.3
100
93.3
N.A.
86.6
40
N.A.
46.6
N.A.
N.A.
6.6
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
100
26.6
100
93.3
N.A.
93.3
46.6
N.A.
66.6
N.A.
N.A.
13.3
N.A.
N.A.
N.A.
66.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
12
12
0
0
56
67
0
12
78
0
0
45
0
0
% A
% Cys:
0
0
0
0
0
0
23
0
0
0
0
0
0
0
0
% C
% Asp:
12
12
0
0
0
12
0
0
23
0
0
0
0
0
0
% D
% Glu:
0
67
0
12
23
0
0
0
0
0
0
0
23
0
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% F
% Gly:
0
0
0
0
12
0
0
12
12
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% H
% Ile:
12
0
0
0
0
0
0
0
0
12
0
0
0
45
0
% I
% Lys:
12
0
0
0
56
0
0
23
0
0
0
78
0
0
0
% K
% Leu:
0
0
0
0
0
0
12
12
0
12
67
0
23
12
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
12
% N
% Pro:
23
12
0
0
0
0
0
0
0
0
12
0
0
0
0
% P
% Gln:
0
0
12
0
0
0
0
0
12
0
0
0
0
0
0
% Q
% Arg:
0
0
67
0
12
0
0
0
45
0
0
0
0
0
12
% R
% Ser:
45
0
0
23
0
0
0
45
0
0
12
0
12
23
56
% S
% Thr:
0
0
12
0
0
23
0
12
0
0
0
12
0
0
0
% T
% Val:
0
0
0
0
0
12
0
0
0
0
0
0
0
23
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
67
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _